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Try out PMC Labs and tell us what you think. Learn More. Pluripotent cells can be derived from fibroblasts by ectopic expression of defined transcription factors. A fundamental unresolved question is whether terminally differentiated cells can be reprogrammed to pluripotency. We utilized transgenic and inducible expression of four transcription factors Oct4, Sox2, Klf4, and c-Myc to reprogram mouse B lymphocytes.
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Jacob Hanna Lab
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The system can't perform the operation now. Try again later. Citations per year. Duplicate citations. The following articles are merged in Scholar. Their combined citations are counted only for the first article.
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Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency
The Buenrostro lab is broadly dedicated to advancing our knowledge of gene regulation and the downstream consequences on cell fate decisions. Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nature biotechnology.
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